Last but not least is the San Francisco SPCA; the SPCA stands for Society for the Prevention of Cruelty to Animals. Incredibly, it is 12 years older than the previously mentioned San Diego Humane Society and SPCA, founded in 1868. "Simply put: the SF SPCA cares," it says on its website. And they mean it. The organization launched its Vision 2020 plan last year, which is setting out to end animal abandonment in San Francisco by the year 2020. The San Francisco SPCA coordinates dog and cat adoptions; operates a veterinary hospital, the Leanne B. Roberts Animal Care Center; runs youth programs, training meetings, and therapy sessions; and has many more initiatives. Like its San Diego counterpart, the SPCA does not accept financing from any federal or state sources, only local donors in the San Francisco metropolitan area.

The San Francisco SPCA was founded in 1868.