Sean Parker, cofounder of Napster, is better known for his role as Facebook's founding president. Mr. Parker donated 22 percent of his worth last year, ranking #268 on the Forbes 400 with a net worth of $2.5 billion. Parker donated a collective $550 million to his Sean N. Parker Foundation, including a $24 million grant to establish the Sean N. Parker Center for Allergy Research at Stanford University. The center will work to find better treatments and lasting cures to allergies.

Brendan McDermid/Reuters
Entrepreneur Sean Parker, founder of Napster, takes part in a panel during the Clinton Global Initiative's annual meeting in New York, September 29, 2015.